Wednesday August 21 1861

• Brig. Gen. John Breckinridge Grayson, CSA, is assigned to the command of the Confederate Dept. of Middle and East Florida.
• Skirmishes at Jonesborough, MO. (Aug 21-22)
• Brig. Gen. Roswell Sabine Ripley, CSA, is assigned to the command of the Confederate Dept. of South Carolina.

Thursday August 21 1862

• Skirmish at Light Prairie, near Arcata, CA.
• Baton Rouge, LA, is evacuated by the Union forces, and after the Union ironclads Essex and No. 7, laying offshore, threaten to shell the city if occupied by Confederates, a local citizen committee meet with the commander of No. 7, and he promises not to bombard the city.
• Skirmish at Neosho, MO, with Rebel guerrillas.
• Affair on Pinckney Island, SC, with a Confederate surprise attack on a Federal company posted there, with prisoners.
• The Union forces surrender Gallatin, TN.
• Skirmishes along the Rappahannock River, at Kelly's, Beverly (or Cunningham's), and Freeman's Fords, etc., VA.
• The 3rd US Army Corps sails from Yorktown, VA, for Alexandria, and Aquia Creek, VA.

Friday August 21 1863

• Skirmish at Maysville, AL, the Chickamauga Campaign.
• The massacre at Lawrence, KS, by the Confederate irregular guerrilla raiders under William Clarke Quantrill, killing over 150 citizens.
• Skirmish near Brooklyn, KS, with Quantrill's guerrillas.
• Skirmish near Paola, KS, with Quantrill's guerrillas.
• Brig. Gen. Robert B. Potter, USA, assumes the command of the 9th US Army Corps, KY.
• Skirmish at Coldwater, MS.
• The Bombardment of Charleston, SC, begins tonight by Brig. Gen. Quincy Adams Gillmore, USA, because Fort Sumter refuses to surrender. Gillmore is firing the Swamp Angel, a huge battery that fires 200 Ib shells. (Aug 21-Dec 31)
• The bombardment of Chattanooga, TN, by Maj. Gen. Williams S. Rosecrans, USA, the Chickamauga Campaign.
• Action at Shellmound, TN, the Chickamauga Campaign.
• Maj. Gen. John G. Foster, USA, resumes the command of the 18th US Army Corps, TN.
• Skirmish near Glenville, WV, with Confederate guerrillas.

Sunday August 21 1864

• Brig. Gen. John Caldwell Calhoun Sanders, CSA, is mortally wounded during the siege of Petersburg, VA, on the Weldon Railroad, bleeding to death after having both of his femoral arteries in his thighs severed by a Federal Minie ball.
• Federal expedition in Washington and Benton Counties, AR, with skirmishes with Indians and bushwackers in the vicinity of Cane Hill. (Aug 21-27)
• The Skirmish at Grubb's Cross-Roads, KY.
• Skirmish at Diamond Grove, MO.
• The Confederate attack on, and occupation of Memphis, TN, by Maj. Gen. Nathan Bedford Forrest, CSA, as he captures about 250-100 days men.
• Skirmishes at Rogersville (Aug 21) and at Blue Springs (Aug 23), and pursuit of the Confederates to Greeneville, TN. (Aug 21-23)
• Gen. Robert E. Lee, CSA, concedes the Weldon Railroad, a vital railroad link of Richmond and Petersburg, after Lieut. Gen. A. P. Hill's attack on the Federal lines fails.
• Skirmish near Berryville, VA, the Shenandoah Valley, VA, Campaign.
• Skirmish in Loudoun County, near Leesville, VA, with the Federals capturing a small band of Lieut. Col. John S. Mosby's men.
• Skirmish at Middleway, WV, the Shenandoah Valley, VA, Campaign.
• Skirmish near Summit Point, WV, the Shenandoah Valley, VA, Campaign.
• Skirmish at Welch's (or Flowing) Spring, near Charlestown, WV, the Shenandoah Valley, VA, Campaign.

Monday August 21 1865